Publications 2018

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PUBLICATIONS

J. Med. Chem. 2018, 61, 1969-1989

Increased Potency and Selectivity for Group III Metabotropic Glutamate Receptor Agonists Binding at

C. Selvam, I. A. Lemasson, I. Brabet, N. Oueslati, B. Karaman, A. Cabaye, A. S. Tora, B. Commare, T. Courtiol, S. Cesarini, I. McCort-Tranchepain, D. Rigault, L. Mony, T. Bessiron, H. McLean, F. R. Leroux, F. Colobert, H. Daniel, A. Goupil-Lamy, H.-O. Bertrand, C. Goudet, J.-P. Pin, F. C. Acher

Eur. J. Org. Chem. 2018, 3792-3802

2,4‐Bis(fluoroalkyl)quinoline‐3‐carboxylates as tools for the development of potential agrochemical ingredients

F. Aribi, A. Panossian, J.-P. Vors, S. Pazenok, F. R. Leroux

New J. Chem. 2018, 42, 10036-10047

A Physico-chemical Investigation on Fluorine-Enriched Quinolines

F. Aribi, A. Panossian, D. Jacquemin, J.-P. Vors, S. Pazenok, F. R. Leroux, M. Elhabiri

J. Org. Chem. 2018, 83, 7751-7761

Stereoselectivity Switch in the Trapping of Polar Organometallics with Andersen’s Reagent—Access to Highly Stereoenriched Transformable Biphenyls

J. Bortoluzzi, V. Jha, G. Levitre, M. J. Fer, J. Berreur, G. Masson, A. Panossian, F. R. Leroux

Chem. Eur. J. 2018, 24, 1311-1316

Synthesis of mono- and bis(fluoroalkyl)-pyrimidines from FARs, fluorinated acetoacetates and malononitrile – Easy access to novel high value pyrimidine agrophores

E. Schmitt, B. Commare, A. Panossian, J.-P. Vors, S. Pazenok, F. R. Leroux

Eur. J. Med. Chem. 2018, 143, 473-490

A Fluorine Scan of a Tubulin Polymerization Inhibitor isoCombretastatin A-4: Design, Synthesis, Molecular Modelling, and Biological Evaluation

T. Nareta, J. Bignon, G. Bernadata, M. Benchekrouna, H. Levaique, C. Lenoir, J. Dubois, A. Pruvost, F. Saller, D. Borgel, B. Manoury, V. Leblaise, R. Darrigrand, S. Apcher, J.-D. Brion, E. Schmitt, F. R. Leroux, M. Alami, A. Hamze

Chem. Commun. 2018, 54, 10423-10426

Access towards enantiopure α,α-difluoromethyl alcohols by means of sulfoxides as traceless chiral auxiliaries

C. Batisse, A. Panossian, G. Hanquet, F. Leroux

A new methodology to access enantiopure α,α-difluoromethyl alcohols is hereby being described. The strategy relies on the use of an enantiopure aryl α,α-difluoromethyl sulfoxide employed as chiral and removable auxiliary for the stereoselective difluoromethylation of carbonyl derivatives. The obtained α,α-difluoro-β-hydroxysulfoxides displayed unprecedented diastereomeric ratios.

J. Fluorine Chem. 2018, 214, 17-23

New synthetic access to 3-fluoroalkyl-5-pyrazolecarboxylates and carboxylic acids

A. Gómez Herrera, E. Schmitt, A. Panossian, J.-P. Vors, S. Pazenok, F. R. Leroux

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