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   J. Med. Chem. 2018, 61, 1969-1989
Increased Potency and Selectivity for Group III Metabotropic Glutamate Receptor Agonists Binding at
C. Selvam, I. A. Lemasson, I. Brabet, N. Oueslati, B. Karaman, A. Cabaye, A. S. Tora, B. Commare, T. Courtiol, S. Cesarini, I. McCort-Tranchepain, D. Rigault, L. Mony, T. Bessiron, H. McLean, F. R. Leroux, F. Colobert, H. Daniel, A. Goupil-Lamy, H.-O. Bertrand, C. Goudet, J.-P. Pin, F. C. Acher
 Eur. J. Org. Chem. 2018, 3792-3802

2,4‐Bis(fluoroalkyl)quinoline‐3‐carboxylates as tools for the development of potential agrochemical ingredients

F. Aribi, A. Panossian, J.-P. Vors, S. Pazenok, F. R. Leroux

   New J. Chem. 2018, 42, 10036-10047

A Physico-chemical Investigation on Fluorine-Enriched Quinolines

F. Aribi, A. Panossian, D. Jacquemin, J.-P. Vors, S. Pazenok, F. R. Leroux, M. Elhabiri

  J. Org. Chem. 2018, 83, 7751-7761
Stereoselectivity Switch in the Trapping of Polar Organometallics with Andersen’s Reagent—Access to Highly Stereoenriched Transformable Biphenyls

J. Bortoluzzi, V. Jha, G. Levitre, M. J. Fer, J. Berreur, G. Masson, A. Panossian, F. R. Leroux

  Chem. Eur. J. 2018, 24, 1311-1316
Synthesis of mono- and bis(fluoroalkyl)-pyrimidines from FARs, fluorinated acetoacetates and malononitrile – Easy access to novel high value pyrimidine agrophores

E. Schmitt, B. Commare, A. Panossian, J.-P. Vors, S. Pazenok, F. R. Leroux

  Eur. J. Med. Chem. 2018, 143, 473-490
A Fluorine Scan of a Tubulin Polymerization Inhibitor isoCombretastatin A-4: Design, Synthesis, Molecular Modelling, and Biological Evaluation

T. Nareta, J. Bignon, G. Bernadata, M. Benchekrouna, H. Levaique, C. Lenoir, J. Dubois, A. Pruvost, F. Saller, D. Borgel, B. Manoury, V. Leblaise, R. Darrigrand, S. Apcher, J.-D. Brion, E. Schmitt, F. R. Leroux, M. Alami, A. Hamze

 Chem. Commun. 2018, 54, 10423-10426

Access towards enantiopure α,α-difluoromethyl alcohols by means of sulfoxides as traceless chiral auxiliaries

C. Batisse, A. Panossian, G. Hanquet, F. Leroux

A new methodology to access enantiopure α,α-difluoromethyl alcohols is hereby being described. The strategy relies on the use of an enantiopure aryl α,α-difluoromethyl sulfoxide employed as chiral and removable auxiliary for the stereoselective difluoromethylation of carbonyl derivatives. The obtained α,α-difluoro-β-hydroxysulfoxides displayed unprecedented diastereomeric ratios.

 J. Fluorine Chem. 2018, 214, 17-23

New synthetic access to 3-fluoroalkyl-5-pyrazolecarboxylates and carboxylic acids

A. Gómez Herrera, E. Schmitt, A. Panossian, J.-P. Vors, S. Pazenok, F. R. Leroux

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